Distinct NF-κB and MAPK activation thresholds uncouple steady-state microbe sensing from anti-pathogen inflammatory responses

The innate immune system distinguishes low-level homeostatic microbial stimuli from those of invasive pathogens, yet we lack understanding of how qualitatively similar microbial products yield context-specific macrophage functional responses. Using quantitative approaches, we found that NF-κB and MA...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Cell Syst
Autori principali: Gottschalk, Rachel A., Martins, Andrew J., Angermann, Bastian R., Dutta, Bhaskar, Ng, Caleb E., Uderhardt, Stefan, Tsang, John S., Fraser, Iain D.C., Meier-Schellersheim, Martin, Germain, Ronald N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4919147/
https://ncbi.nlm.nih.gov/pubmed/27237739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2016.04.016
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi