Distinct NF-κB and MAPK activation thresholds uncouple steady-state microbe sensing from anti-pathogen inflammatory responses

The innate immune system distinguishes low-level homeostatic microbial stimuli from those of invasive pathogens, yet we lack understanding of how qualitatively similar microbial products yield context-specific macrophage functional responses. Using quantitative approaches, we found that NF-κB and MA...

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Publicado no:Cell Syst
Main Authors: Gottschalk, Rachel A., Martins, Andrew J., Angermann, Bastian R., Dutta, Bhaskar, Ng, Caleb E., Uderhardt, Stefan, Tsang, John S., Fraser, Iain D.C., Meier-Schellersheim, Martin, Germain, Ronald N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4919147/
https://ncbi.nlm.nih.gov/pubmed/27237739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2016.04.016
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