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Silencing of aberrant secretory protein expression by disease-associated mutations

Signal Recognition Particle (SRP) recognizes signal sequences of secretory proteins and targets them to the endoplasmic reticulum membrane for translocation. Many human diseases are connected with defects in signal sequences. The current dogma states that the molecular basis of the disease-associate...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Mol Biol
Prif Awduron: Tikhonova, Elena B., Karamysheva, Zemfira N., von Heijne, Gunnar, Karamyshev, Andrey L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6684239/
https://ncbi.nlm.nih.gov/pubmed/31100385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2019.05.011
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