IL-27 promotes the expansion of self-renewing CD8(+) T cells in persistent viral infection

Chronic infection and cancer are associated with suppressed T cell responses in the presence of cognate antigen. Recent work identified memory-like CXCR5(+) TCF1(+) CD8(+) T cells that sustain T cell responses during persistent infection and proliferate upon anti-PD1 treatment. Approaches to expand...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Exp Med
Main Authors: Huang, Zhe, Zak, Jaroslav, Pratumchai, Isaraphorn, Shaabani, Namir, Vartabedian, Vincent F., Nguyen, Nhan, Wu, Tuoqi, Xiao, Changchun, Teijaro, John R.
Format: Artigo
Jezik:Inglês
Izdano: Rockefeller University Press 2019
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6683984/
https://ncbi.nlm.nih.gov/pubmed/31164392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20190173
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