IL-27 Limits Central Nervous System Viral Clearance by Promoting IL-10 and Enhances Demyelination

IL-27 is a pleiotropic member of the IL-6 and IL-12 cytokine family composed of the IL-27p28 and the EBV-induced gene 3. IL-27 and its receptor mRNA are both upregulated in the CNS during acute encephalomyelitis induced by the JHM strain of mouse hepatitis virus (JHMV) and sustained during viral per...

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Bibliographic Details
Main Authors: de Aquino, Maria Teresa P., Kapil, Parul, Hinton, David R., Phares, Timothy W., Puntambekar, Shweta S., Savarin, Carine, Bergmann, Cornelia C., Stohlman, Stephen A.
Format: Artigo
Language:Inglês
Published: AAI 2014
Subjects:
Infectious Disease and Host Response
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067872/
https://ncbi.nlm.nih.gov/pubmed/24890725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1400058
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