Regulation of heart rate and the pacemaker current by phosphoinositide 3-kinase signaling

Heart rate in physiological conditions is set by the sinoatrial node (SN), the primary cardiac pacing tissue. Phosphoinositide 3-kinase (PI3K) signaling is a major regulatory pathway in all normal cells, and its dysregulation is prominent in diabetes, cancer, and heart failure. Here, we show that in...

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Detalles Bibliográficos
Publicado en:J Gen Physiol
Main Authors: Lin, Richard Z., Lu, Zhongju, Anyukhovsky, Evgeny P., Jiang, Ya-Ping, Wang, Hong Zhan, Gao, Junyuan, Rosen, Michael R., Ballou, Lisa M., Cohen, Ira S.
Formato: Artigo
Idioma:Inglês
Publicado: Rockefeller University Press 2019
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Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6683667/
https://ncbi.nlm.nih.gov/pubmed/31217223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201812293
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