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Suppression of Phosphoinositide 3-Kinase Signaling and Alteration of Multiple Ion Currents in Drug-Induced Long QT Syndrome

Many drugs, including some commonly used medications, can cause abnormal heart rhythms and sudden death, as manifest by a prolonged QT interval in the electrocardiogram. Cardiac arrhythmias caused by drug-induced long QT syndrome are thought to result mainly from reductions in the delayed rectifier...

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Detalhes bibliográficos
Main Authors: Lu, Zhongju, Wu, Chia-Yen C., Jiang, Ya-Ping, Ballou, Lisa M., Clausen, Chris, Cohen, Ira S., Lin, Richard Z.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494282/
https://ncbi.nlm.nih.gov/pubmed/22539774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3003623
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