Deep Mining of Complex Antibody Phage Pools Generated by Cell Panning Enables Discovery of Rare Antibodies Binding New Targets and Epitopes

Phage display technology is a common approach for discovery of therapeutic antibodies. Drug candidates are typically isolated in two steps: First, a pool of antibodies is enriched through consecutive rounds of selection on a target antigen, and then individual clones are characterized in a screening...

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Detaylı Bibliyografya
Yayımlandı:Front Pharmacol
Asıl Yazarlar: Ljungars, Anne, Svensson, Carolin, Carlsson, Anders, Birgersson, Elin, Tornberg, Ulla-Carin, Frendéus, Björn, Ohlin, Mats, Mattsson, Mikael
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2019
Konular:
Pharmacology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6683657/
https://ncbi.nlm.nih.gov/pubmed/31417405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00847
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