CD40/anti-CD40 antibody complexes which illustrate agonist and antagonist structural switches

BACKGROUND: CD40 is a 48 kDa type I transmembrane protein that is constitutively expressed on hematopoietic cells such as dendritic cells, macrophages, and B cells. Engagement of CD40 by CD40L expressed on T cells results in the production of proinflammatory cytokines, induces T helper cell function...

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Bibliografiske detaljer
Udgivet i:BMC Mol Cell Biol
Main Authors: Argiriadi, Maria A., Benatuil, Lorenzo, Dubrovska, Ievgeniia, Egan, David A., Gao, Lei, Greischar, Amy, Hardman, Jennifer, Harlan, John, Iyer, Ramesh B., Judge, Russell A., Lake, Marc, Perron, Denise C., Sadhukhan, Ramkrishna, Sielaff, Bernhard, Sousa, Silvino, Wang, Rui, McRae, Bradford L.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6683420/
https://ncbi.nlm.nih.gov/pubmed/31382872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12860-019-0213-4
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