A polymorphic CD40 ligand (CD154) molecule mediates CD40‐dependent signalling but interferes with the ability of soluble CD40 to functionally block CD154 : CD40 interactions

We report the characterization of a naturally occurring polymorphism in CD40 ligand (CD40L, CD154) expressed by activated T cells from a young female patient. This polymorphism encodes a nonconservative Gly → Arg substitution in amino acid 219 in the extracellular, CD40 binding domain of the molecul...

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Bibliographic Details
Main Authors: Barnhart, B, Ford, G S, Bhushan, A, Song, C, Covey, L R
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2000
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2327125/
https://ncbi.nlm.nih.gov/pubmed/10651941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2567.2000.00943.x
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