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Treatment with a CD40 Antagonist Antibody Reverses Severe Proteinuria and Loss of Saliva Production and Restores Glomerular Morphology in Murine Systemic Lupus Erythematosus

CD40 is a costimulatory receptor on APCs that is critical for the induction and maintenance of humoral and cell-mediated immunity. Accordingly, CD40 and its ligand, CD40L, have long been considered targets for the treatment of autoimmune diseases. We developed a rat/mouse chimeric anti-mouse CD40 an...

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محفوظ في:

التفاصيل البيبلوغرافية
الحاوية / القاعدة:	J Immunol
المؤلفون الرئيسيون:	Perper, Stuart J., Westmoreland, Susan V., Karman, Jozsef, Twomey, Rachel, Seagal, Jane, Wang, Rui, McRae, Bradford L., Clarke, Stephen H.
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	AAI 2019
الموضوعات:	Autoimmunity
الوصول للمادة أونلاين:	https://ncbi.nlm.nih.gov/pmc/articles/PMC6571503/ https://ncbi.nlm.nih.gov/pubmed/31109957 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1900043
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Treatment with a CD40 Antagonist Antibody Reverses Severe Proteinuria and Loss of Saliva Production and Restores Glomerular Morphology in Murine Systemic Lupus Erythematosus

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