Deficiency in the phosphatase PHLPP1 suppresses osteoclast-mediated bone resorption and enhances bone formation in mice

Enhanced osteoclast-mediated bone resorption and diminished formation may promote bone loss. Pleckstrin homology (PH) domain and leucine-rich repeat protein phosphatase 1 (Phlpp1) regulates protein kinase C (PKC) and other proteins in the control of bone mass. Germline Phlpp1 deficiency reduces bone...

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Udgivet i:J Biol Chem
Main Authors: Mattson, Anna M., Begun, Dana L., Molstad, David H. H., Meyer, Margaret A., Oursler, Merry Jo, Westendorf, Jennifer J., Bradley, Elizabeth W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2019
Fag:
Molecular Bases of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6682736/
https://ncbi.nlm.nih.gov/pubmed/31189651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007660
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