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Polyphosphate-Mediated Inhibition of Tartrate-Resistant Acid Phosphatase and Suppression of Bone Resorption of Osteoclasts

Inorganic polyphosphate (poly(P)) has recently been found to play an important role in bone formation. In this study, we found that tartrate-resistant acid phosphatase (TRAP), which is abundantly expressed in osteoclasts, has polyphosphatase activity that degrades poly(P) and yields Pi as well as sh...

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Detalhes bibliográficos
Main Authors: Harada, Kana, Itoh, Hiromichi, Kawazoe, Yumi, Miyazaki, Shuichi, Doi, Kazuya, Kubo, Takayasu, Akagawa, Yasumasa, Shiba, Toshikazu
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3817253/
https://ncbi.nlm.nih.gov/pubmed/24223830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0078612
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