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Tools for Building, Analyzing and Evaluating HLA Haplotypes from Families

The highly polymorphic classical human leukocyte antigen (HLA) genes display strong linkage disequilibrium (LD) that results in conserved multi-locus haplotypes. For unrelated individuals in defined populations, HLA haplotype frequencies can be estimated using the expectation-maximization (EM) metho...

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Bibliografski detalji
Izdano u:Hum Immunol
Glavni autori: Osoegawa, Kazutoyo, Mack, Steven J., Prestegaard, Matthew, Fernández-Viña, Marcelo A.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6682467/
https://ncbi.nlm.nih.gov/pubmed/30735756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.humimm.2019.01.010
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