High Resolution Haplotype Analyses of Classical HLA Genes in Families With Multiple Sclerosis Highlights the Role of HLA-DP Alleles in Disease Susceptibility

Multiple sclerosis (MS) susceptibility shows strong genetic associations with HLA alleles and haplotypes. We genotyped 11 HLA genes in 477 non-Hispanic European MS patients and their 954 unaffected parents using a validated next-generation sequencing (NGS) methodology. HLA haplotypes were assigned u...

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Veröffentlicht in:Front Immunol
Hauptverfasser: Osoegawa, Kazutoyo, Creary, Lisa E., Montero-Martín, Gonzalo, Mallempati, Kalyan C., Gangavarapu, Sridevi, Caillier, Stacy J., Santaniello, Adam, Isobe, Noriko, Hollenbach, Jill A., Hauser, Stephen L., Oksenberg, Jorge R., Fernández-Viňa, Marcelo A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2021
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8240666/
https://ncbi.nlm.nih.gov/pubmed/34211458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.644838
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