Low mutation burden and frequent loss of CDKN2A/B and SMARCA2, but not PRC2, define premalignant neurofibromatosis type 1–associated atypical neurofibromas

BACKGROUND: Neurofibromatosis type 1 (NF1) is a tumor-predisposition disorder caused by germline mutations in NF1. NF1 patients have an 8–16% lifetime risk of developing a malignant peripheral nerve sheath tumor (MPNST), a highly aggressive soft-tissue sarcoma, often arising from preexisting benign...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Pemov, Alexander, Hansen, Nancy F, Sindiri, Sivasish, Patidar, Rajesh, Higham, Christine S, Dombi, Eva, Miettinen, Markku M, Fetsch, Patricia, Brems, Hilde, Chandrasekharappa, Settara C, Jones, Kristine, Zhu, Bin, Wei, Jun S, Mullikin, James C, Wallace, Margaret R, Khan, Javed, Legius, Eric, Widemann, Brigitte C, Stewart, Douglas R
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
Fag:
Basic and Translational Investigations
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6682216/
https://ncbi.nlm.nih.gov/pubmed/30722027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz028
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