Computational and Experimental Druggability Assessment of Human DNA Glycosylases

[Image: see text] Due to a polar or even charged binding interface, DNA-binding proteins are considered extraordinarily difficult targets for development of small-molecule ligands and only a handful of proteins have been targeted successfully to date. Recently, however, it has been shown that develo...

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Veröffentlicht in:ACS Omega
Hauptverfasser: Michel, Maurice, Visnes, Torkild, Homan, Evert J., Seashore-Ludlow, Brinton, Hedenström, Mattias, Wiita, Elisée, Vallin, Karl, Paulin, Cynthia B. J., Zhang, Jiaxi, Wallner, Olov, Scobie, Martin, Schmidt, Andreas, Jenmalm-Jensen, Annika, Warpman Berglund, Ulrika, Helleday, Thomas
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2019
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6682003/
https://ncbi.nlm.nih.gov/pubmed/31460271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.9b00162
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