Molecular determinants of homo- and heteromeric interactions of Junctophilin-1 at triads in adult skeletal muscle fibers

In adult skeletal muscles, 2 junctophilin isoforms (JPH1 and JPH2) tether the sarcoplasmic reticulum (SR) to transverse tubule (T-tubule) membranes, generating stable membrane contact sites known as triads. JPHs are anchored to the membrane of the SR by a C-terminal transmembrane domain (TMD) and bi...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Rossi, Daniela, Scarcella, Angela Maria, Liguori, Enea, Lorenzini, Stefania, Pierantozzi, Enrico, Kutchukian, Candice, Jacquemond, Vincent, Messa, Mirko, De Camilli, Pietro, Sorrentino, Vincenzo
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2019
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6681751/
https://ncbi.nlm.nih.gov/pubmed/31315980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1820980116
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