Dose–response, therapeutic time-window and tPA-combinatorial efficacy of compound 21: A randomized, blinded preclinical trial in a rat model of thromboembolic stroke

The aim of this translational, randomized, controlled, blinded preclinical trial was to determine the effect of compound 21 (C21) in embolic stroke. Rats were subjected to embolic-middle cerebral artery occlusion (eMCAO). They received C21 (0.01, 0.03 and 0.06 mg/kg/d) or saline (orally) for five da...

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Vydáno v:J Cereb Blood Flow Metab
Hlavní autoři: Ishrat, Tauheed, Fouda, Abdelrahman Y, Pillai, Bindu, Eldahshan, Wael, Ahmed, Heba, Waller, Jennifer L, Ergul, Adviye, Fagan, Susan C
Médium: Artigo
Jazyk:Inglês
Vydáno: SAGE Publications 2018
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6681526/
https://ncbi.nlm.nih.gov/pubmed/29537907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X18764773
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