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Effect of Ticagrelor, a Cytochrome P450 3A4 Inhibitor, on the Pharmacokinetics of Tadalafil in Rats

Tadalafil is a cytochrome P450 (CYP) 3A4 substrate. Because there are few data on drug-drug interactions, it is advisable to take sufficient consideration when co-administering tadalafil with CYP3A4 inducers or inhibitors. This study was conducted to assess the effect of ticagrelor, a CYP3A4 inhibit...

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Библиографические подробности
Опубликовано в: :Pharmaceutics
Главные авторы: Na, Young-Guk, Byeon, Jin-Ju, Huh, Hyun Wook, Kim, Min-Ki, Shin, Young G., Lee, Hong-Ki, Cho, Cheong-Weon
Формат: Artigo
Язык:Inglês
Опубликовано: MDPI 2019
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6680770/
https://ncbi.nlm.nih.gov/pubmed/31330787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics11070354
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