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Pharmacokinetics and pharmacodynamics of cytochrome P450 inhibitors for HIV treatment

INTRODUCTION: Drugs used in HIV treatment; all protease inhibitors, some non-nucleoside reverse transcriptase inhibitors, and pharmacoenhancers ritonavir and cobicistat can inhibit cytochrome P450 (CYP) enzymes. CYP inhibition can cause clinically significant drug-drug interactions (DDI), leading to...

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Detalhes bibliográficos
Publicado no:Expert Opin Drug Metab Toxicol
Main Authors: Gong, Yuqing, Haque, Sanjana, Chowdhury, Pallabita, Cory, Theodore J., Kodidela, Sunitha, Yallapu, Murali M., Norwood, John M., Kumar, Santosh
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497396/
https://ncbi.nlm.nih.gov/pubmed/30951643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/17425255.2019.1604685
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