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Brain Delivery of Thyrotropin-Releasing Hormone via a Novel Prodrug Approach

Using thyrotropin-releasing hormone (TRH) as a model, we explored whether synergistic combination of lipoamino acid(s) and a linker cleaved by prolyl oligopeptidase (POP) can be used as a promoiety for prodrug design for the preferential brain delivery of the peptide. A representative prodrug based...

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Bibliografische gegevens
Gepubliceerd in:Pharmaceutics
Hoofdauteurs: Prokai-Tatrai, Katalin, De La Cruz, Daniel L., Nguyen, Vien, Ross, Benjamin P., Toth, Istvan, Prokai, Laszlo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2019
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6680701/
https://ncbi.nlm.nih.gov/pubmed/31323784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics11070349
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