Cholesterol Crystals Induce Coagulation Activation through Complement-Dependent Expression of Monocytic Tissue Factor

Cholesterol crystals (CC) are strong activators of complement and could potentially be involved in thromboinflammation through complement–coagulation cross-talk. To explore the coagulation-inducing potential of CC, we performed studies in lepirudin-based human whole blood and plasma models. In addit...

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Veröffentlicht in:J Immunol
Hauptverfasser: Gravastrand, Caroline S., Steinkjer, Bjørg, Halvorsen, Bente, Landsem, Anne, Skjelland, Mona, Jacobsen, Eva Astrid, Woodruff, Trent M., Lambris, John D., Mollnes, Tom E., Brekke, Ole-Lars, Espevik, Terje, Rokstad, Anne Mari A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: AAI 2019
Schlagworte:
Clinical and Human Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6680065/
https://ncbi.nlm.nih.gov/pubmed/31270150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1900503
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