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The specificity of ubiquitin binding to ubiquilin-1 is regulated by sequences besides its UBA domain
UBQLN proteins regulate proteostasis by facilitating clearance of misfolded proteins through the proteasome and autophagy degradation pathways. Consistent with its proteasomal function, UBQLN proteins contain both UBL and UBA domains, which bind subunits of the proteasome, including the S5a subunit,...
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| Publicado no: | Biochim Biophys Acta Gen Subj |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6679980/ https://ncbi.nlm.nih.gov/pubmed/31175912 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2019.06.002 |
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