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TGF-β family ligands exhibit distinct signalling dynamics that are driven by receptor localisation

Growth factor-induced signal transduction pathways are tightly regulated at multiple points intracellularly, but how cells monitor levels of extracellular ligand and translate this information into appropriate downstream responses remains unclear. Understanding signalling dynamics is thus a key chal...

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Detalhes bibliográficos
Publicado no:J Cell Sci
Main Authors: Miller, Daniel S. J., Schmierer, Bernhard, Hill, Caroline S.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6679586/
https://ncbi.nlm.nih.gov/pubmed/31217285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.234039
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