Tanshinone IIA Restores Dynamic Balance of Autophagosome/Autolysosome in Doxorubicin-Induced Cardiotoxicity via Targeting Beclin1/LAMP1

Clinical use of the anti-cancer drug doxorubicin (DOX) is largely limited due to its severe cardiotoxicity. Dysregulation of autophagy is implicated in DOX-induced cardiotoxicity (DIC). Prior studies have indicated that Beclin1 and lysosomal-associated membrane proteins-1 (LAMP1) are critical mediat...

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Publicat a:Cancers (Basel)
Autors principals: Wang, Xiaoping, Li, Chun, Wang, Qiyan, Li, Weili, Guo, Dongqing, Zhang, Xuefeng, Shao, Mingyan, Chen, Xu, Ma, Lin, Zhang, Qian, Wang, Wei, Wang, Yong
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6679133/
https://ncbi.nlm.nih.gov/pubmed/31261758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11070910
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