A Novel AURKA Mutant-Induced Early-Onset Severe Hepatocarcinogenesis Greater than Wild-Type via Activating Different Pathways in Zebrafish

Aurora A kinase (AURKA) is an important regulator in mitotic progression and is overexpressed frequently in human cancers, including hepatocellular carcinoma (HCC). Many AURKA mutations were identified in cancer patients. Overexpressing wild-type Aurka developed a low incidence of hepatic tumors aft...

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Publicado en:Cancers (Basel)
Autores principales: Su, Zhong-Liang, Su, Chien-Wei, Huang, Yi-Luen, Yang, Wan-Yu, Sampurna, Bonifasius Putera, Ouchi, Toru, Lee, Kuan-Lin, Wu, Chen-Sheng, Wang, Horng-Dar, Yuh, Chiou-Hwa
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6678475/
https://ncbi.nlm.nih.gov/pubmed/31269749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11070927
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