Short-term CFTR inhibition reduces islet area in C57BL/6 mice

Cystic fibrosis-related diabetes (CFRD) worsens CF lung disease leading to early mortality. Loss of beta cell area, even without overt diabetes or pancreatitis is consistently observed. We investigated whether short-term CFTR inhibition was sufficient to impact islet morphology and function in other...

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Publicado no:Sci Rep
Main Authors: Khan, Dawood, Kelsey, Ryan, Maheshwari, Rashmi R., Stone, Virginia M., Hasib, Annie, Manderson Koivula, Fiona N., Watson, Aoife, Harkin, Stephen, Irwin, Nigel, Shaw, James A., McClenaghan, Neville H., Venglovecz, Viktória, Ébert, Attila, Flodström-Tullberg, Malin, White, Michael G., Kelly, Catriona
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6677757/
https://ncbi.nlm.nih.gov/pubmed/31375720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47745-w
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