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PUMILIO, but not RBMX, binding is required for regulation of genomic stability by noncoding RNA NORAD
NORAD is a conserved long noncoding RNA (lncRNA) that is required for genome stability in mammals. NORAD acts as a negative regulator of PUMILIO (PUM) proteins in the cytoplasm, and we previously showed that loss of NORAD or PUM hyperactivity results in genome instability and premature aging in mice...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6677556/ https://ncbi.nlm.nih.gov/pubmed/31343408 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.48625 |
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