PUMILIO hyperactivity drives premature aging of Norad-deficient mice

Although numerous long noncoding RNAs (lncRNAs) have been identified, our understanding of their roles in mammalian physiology remains limited. Here, we investigated the physiologic function of the conserved lncRNA Norad in vivo. Deletion of Norad in mice results in genomic instability and mitochond...

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Detalles Bibliográficos
Publicado en:eLife
Main Authors: Kopp, Florian, Elguindy, Mahmoud M, Yalvac, Mehmet E, Zhang, He, Chen, Beibei, Gillett, Frank A, Lee, Sungyul, Sivakumar, Sushama, Yu, Hongtao, Xie, Yang, Mishra, Prashant, Sahenk, Zarife, Mendell, Joshua T
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications, Ltd 2019
Assuntos:
Chromosomes and Gene Expression
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6407921/
https://ncbi.nlm.nih.gov/pubmed/30735131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.42650
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