PUMILIO hyperactivity drives premature aging of Norad-deficient mice

Although numerous long noncoding RNAs (lncRNAs) have been identified, our understanding of their roles in mammalian physiology remains limited. Here, we investigated the physiologic function of the conserved lncRNA Norad in vivo. Deletion of Norad in mice results in genomic instability and mitochond...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Kopp, Florian, Elguindy, Mahmoud M, Yalvac, Mehmet E, Zhang, He, Chen, Beibei, Gillett, Frank A, Lee, Sungyul, Sivakumar, Sushama, Yu, Hongtao, Xie, Yang, Mishra, Prashant, Sahenk, Zarife, Mendell, Joshua T
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Chromosomes and Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6407921/
https://ncbi.nlm.nih.gov/pubmed/30735131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.42650
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