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Novel drug targets based on metallobiology of Alzheimer’s disease
IMPORTANCE OF THE FIELD: Increased localization of Zn, Fe, Cu and Al within the senile plaques (SP) exacerbates amyloid beta (Aβ)-mediated oxidative damage, and acts as catalyst for Aβ aggregation in Alzheimer’s disease (AD). Thus, disruption of aberrant metal-peptide interactions via chelation ther...
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| Publicado no: | Expert Opin Ther Targets |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6677255/ https://ncbi.nlm.nih.gov/pubmed/20942746 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1517/14728222.2010.525352 |
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