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Conformational diversity induces nanosecond-timescale chemical disorder in the HIV-1 protease reaction pathway

The role of conformational diversity in enzyme catalysis has been a matter of analysis in recent studies. Pre-organization of the active site has been pointed out as the major source for enzymes' catalytic power. Following this line of thought, it is becoming clear that specific, instantaneous,...

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Publicat a:Chem Sci
Autors principals: Calixto, Ana Rita, Ramos, Maria João, Fernandes, Pedro Alexandrino
Format: Artigo
Idioma:Inglês
Publicat: Royal Society of Chemistry 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6677113/
https://ncbi.nlm.nih.gov/pubmed/31588289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9sc01464k
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