Nanosecond-Timescale Dynamics and Conformational Heterogeneity in Human GCK Regulation and Disease

Human glucokinase (GCK) is the prototypic example of an emerging class of proteins with allosteric-like behavior that originates from intrinsic polypeptide dynamics. High-resolution NMR investigations of GCK have elucidated millisecond-timescale dynamics underlying allostery. In contrast, faster mot...

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Bibliographic Details
Published in:Biophys J
Main Authors: Sternisha, Shawn M., Whittington, A. Carl, Martinez Fiesco, Juliana A., Porter, Carol, McCray, Malcolm M., Logan, Timothy, Olivieri, Cristina, Veglia, Gianluigi, Steinbach, Peter J., Miller, Brian G.
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2020
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7063420/
https://ncbi.nlm.nih.gov/pubmed/32023434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2019.12.036
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