Structure of formylglycine-generating enzyme in complex with copper and a substrate reveals an acidic pocket for binding and activation of molecular oxygen

The formylglycine generating enzyme (FGE) catalyzes oxidative conversion of specific peptidyl-cysteine residues to formylglycine. FGE mediates O(2)-activation and hydrogen-atom abstraction in an active site that contains Cu(i) coordinated to two cysteine residues. Similar coordination geometries are...

Full description

Saved in:
Bibliographic Details
Published in:Chem Sci
Main Authors: Miarzlou, Dzmitry A., Leisinger, Florian, Joss, Daniel, Häussinger, Daniel, Seebeck, Florian P.
Format: Artigo
Language:Inglês
Published: Royal Society of Chemistry 2019
Subjects:
Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6676471/
https://ncbi.nlm.nih.gov/pubmed/31588272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9sc01723b
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items