Formylglycine-generating enzyme binds substrate directly at a mononuclear Cu(I) center to initiate O(2) activation

The formylglycine-generating enzyme (FGE) is required for the posttranslational activation of type I sulfatases by oxidation of an active-site cysteine to C(α)-formylglycine. FGE has emerged as an enabling biotechnology tool due to the robust utility of the aldehyde product as a bioconjugation handl...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Appel, Mason J., Meier, Katlyn K., Lafrance-Vanasse, Julien, Lim, Hyeongtaek, Tsai, Chi-Lin, Hedman, Britt, Hodgson, Keith O., Tainer, John A., Solomon, Edward I., Bertozzi, Carolyn R.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2019
Matèries:
Physical Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6431200/
https://ncbi.nlm.nih.gov/pubmed/30824597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1818274116
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