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Single-Molecule Imaging Uncovers Rules Governing Nonsense-Mediated mRNA Decay
Nonsense-mediated decay (NMD) is a surveillance system that degrades mRNAs containing a premature termination codon (PTC) and plays important roles in protein homeostasis and disease. The efficiency of NMD is variable, impacting the clinical outcome of genetic mutations. However, limited resolution...
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| Udgivet i: | Mol Cell |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cell Press
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6675935/ https://ncbi.nlm.nih.gov/pubmed/31155380 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.05.008 |
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