Single-Molecule Imaging Uncovers Rules Governing Nonsense-Mediated mRNA Decay

Nonsense-mediated decay (NMD) is a surveillance system that degrades mRNAs containing a premature termination codon (PTC) and plays important roles in protein homeostasis and disease. The efficiency of NMD is variable, impacting the clinical outcome of genetic mutations. However, limited resolution...

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Udgivet i:Mol Cell
Main Authors: Hoek, Tim A., Khuperkar, Deepak, Lindeboom, Rik G.H., Sonneveld, Stijn, Verhagen, Bram M.P., Boersma, Sanne, Vermeulen, Michiel, Tanenbaum, Marvin E.
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6675935/
https://ncbi.nlm.nih.gov/pubmed/31155380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.05.008
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