Hepatitis B Virus X Protein Function Requires Zinc Binding

The host structural maintenance of chromosomes 5/6 complex (Smc5/6) suppresses hepatitis B virus (HBV) transcription. HBV counters this restriction by expressing the X protein (HBx), which redirects the cellular DNA damage-binding protein 1 (DDB1)-containing E3 ubiquitin ligase to target Smc5/6 for...

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Bibliographic Details
Published in:J Virol
Main Authors: Ramakrishnan, Dhivya, Xing, Weimei, Beran, Rudolf K., Chemuru, Saketh, Rohrs, Henry, Niedziela-Majka, Anita, Marchand, Bruno, Mehra, Upasana, Zábranský, Aleš, Doležal, Michal, Hubálek, Martin, Pichová, Iva, Gross, Michael L., Kwon, Hyock Joo, Fletcher, Simon P.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2019
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6675892/
https://ncbi.nlm.nih.gov/pubmed/31167910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00250-19
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