3-Chloroplumbagin Induces Cell Death in Breast Cancer Cells Through MAPK-Mediated Mcl-1 Inhibition

Resistance acquired toward anti-cancer agents is a significant drawback in breast cancer therapy. A key factor contributing to drug resistance is apoptosis suppression associated with the upregulation of anti-apoptotic Bcl-2 family proteins. Specifically, the anti-apoptotic Mcl-1 protein has been sh...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Kawiak, Anna, Domachowska, Anna, Krolicka, Aleksandra, Smolarska, Monika, Lojkowska, Ewa
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2019
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6675870/
https://ncbi.nlm.nih.gov/pubmed/31404252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00784
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