Targetable mechanisms driving immunoevasion of persistent senescent cells link chemotherapy-resistant cancer to aging

Cellular senescence is a tumor-suppressive mechanism that can paradoxically contribute to aging pathologies. Despite evidence of immune clearance in mouse models, it is not known how senescent cells (SnCs) persist and accumulate with age or in tumors in individuals. Here, we identify cooperative mec...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Muñoz, Denise P., Yannone, Steven M., Daemen, Anneleen, Sun, Yu, Vakar-Lopez, Funda, Kawahara, Misako, Freund, Adam M., Rodier, Francis, Wu, Jennifer D., Desprez, Pierre-Yves, Raulet, David H., Nelson, Peter S., van ’t Veer, Laura J., Campisi, Judith, Coppé, Jean-Philippe
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6675550/
https://ncbi.nlm.nih.gov/pubmed/31184599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.124716
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