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Aberrant DNA methylation defines isoform usage in cancer, with functional implications
Alternative transcript isoforms are common in tumors and act as potential drivers of cancer. Mechanisms determining altered isoform expression include somatic mutations in splice regulatory sites or altered splicing factors. However, since DNA methylation is known to regulate transcriptional isoform...
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| Publicado no: | PLoS Comput Biol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6675117/ https://ncbi.nlm.nih.gov/pubmed/31329578 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007095 |
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