Significant associations between driver gene mutations and DNA methylation alterations across many cancer types

Recent evidence shows that mutations in several driver genes can cause aberrant methylation patterns, a hallmark of cancer. In light of these findings, we hypothesized that the landscapes of tumor genomes and epigenomes are tightly interconnected. We measured this relationship using principal compon...

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Bibliographic Details
Published in:PLoS Comput Biol
Main Authors: Chen, Yun-Ching, Gotea, Valer, Margolin, Gennady, Elnitski, Laura
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5709060/
https://ncbi.nlm.nih.gov/pubmed/29125844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005840
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