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Significant associations between driver gene mutations and DNA methylation alterations across many cancer types
Recent evidence shows that mutations in several driver genes can cause aberrant methylation patterns, a hallmark of cancer. In light of these findings, we hypothesized that the landscapes of tumor genomes and epigenomes are tightly interconnected. We measured this relationship using principal compon...
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| Veröffentlicht in: | PLoS Comput Biol |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5709060/ https://ncbi.nlm.nih.gov/pubmed/29125844 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005840 |
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