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Necdin Downregulates Cdc2 Expression to Attenuate Neuronal Apoptosis
The cell cycle-regulatory transcription factor E2F1 induces apoptosis of postmitotic neurons in developmental and pathological situations. E2F1 transcriptionally activates many proapoptotic genes including the cyclin-dependent protein kinase cell division cycle 2 (Cdc2). Necdin is a potent mitotic s...
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| Publicado no: | J Neurosci |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Society for Neuroscience
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6674873/ https://ncbi.nlm.nih.gov/pubmed/17108174 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3002-06.2006 |
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