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Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults
Neurons rely heavily on mitochondria for their function and survival. Mitochondrial dysfunction contributes to the pathogenesis of neurodegenerative diseases such as Parkinson's disease. PGC-1α is a master regulator of mitochondrial biogenesis and function. Here we identify necdin as a potent P...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4793078/ https://ncbi.nlm.nih.gov/pubmed/26971449 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10943 |
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