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Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults
Neurons rely heavily on mitochondria for their function and survival. Mitochondrial dysfunction contributes to the pathogenesis of neurodegenerative diseases such as Parkinson's disease. PGC-1α is a master regulator of mitochondrial biogenesis and function. Here we identify necdin as a potent P...
Kaydedildi:
| Yayımlandı: | Nat Commun |
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| Asıl Yazarlar: | , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Nature Publishing Group
2016
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4793078/ https://ncbi.nlm.nih.gov/pubmed/26971449 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10943 |
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