α-Synuclein Overexpression in PC12 and Chromaffin Cells Impairs Catecholamine Release by Interfering with a Late Step in Exocytosis

α-Synuclein (α-syn), a protein implicated in Parkinson's disease pathogenesis, is a presynaptic protein suggested to regulate transmitter release. We explored how α-syn overexpression in PC12 and chromaffin cells, which exhibit low endogenous α-syn levels relative to neurons, affects catecholam...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Larsen, Kristin E., Schmitz, Yvonne, Troyer, Matthew D., Mosharov, Eugene, Dietrich, Paula, Quazi, Abrar Z., Savalle, Magali, Nemani, Venu, Chaudhry, Farrukh A., Edwards, Robert H., Stefanis, Leonidas, Sulzer, David
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2006
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6674868/
https://ncbi.nlm.nih.gov/pubmed/17108165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3821-06.2006
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