Inositol 1,4,5-Trisphosphate Receptor Type 1 in Granule Cells, Not in Purkinje Cells, Regulates the Dendritic Morphology of Purkinje Cells through Brain-Derived Neurotrophic Factor Production

Here, we show that cultured Purkinje cells from inositol 1,4,5-trisphosphate receptor type 1 knock-out (IP(3)R1KO) mice exhibited abnormal dendritic morphology. Interestingly, despite the huge amount of IP(3)R1 expression in Purkinje cells, IP(3)R1 in granule cells, not in the Purkinje cells, was re...

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Pubblicato in:J Neurosci
Autori principali: Hisatsune, Chihiro, Kuroda, Yukiko, Akagi, Takumi, Torashima, Takashi, Hirai, Hirokazu, Hashikawa, Tsutomu, Inoue, Takafumi, Mikoshiba, Katsuhiko
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6674761/
https://ncbi.nlm.nih.gov/pubmed/17050730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3269-06.2006
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