Aberrant calcium signaling by transglutaminase-mediated posttranslational modification of inositol 1,4,5-trisphosphate receptors

The inositol 1,4,5-trisphosphate receptor (IP(3)R) in the endoplasmic reticulum mediates calcium signaling that impinges on intracellular processes. IP(3)Rs are allosteric proteins comprising four subunits that form an ion channel activated by binding of IP(3) at a distance. Defective allostery in I...

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Detalhes bibliográficos
Main Authors: Hamada, Kozo, Terauchi, Akiko, Nakamura, Kyoko, Higo, Takayasu, Nukina, Nobuyuki, Matsumoto, Nagisa, Hisatsune, Chihiro, Nakamura, Takeshi, Mikoshiba, Katsuhiko
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183345/
https://ncbi.nlm.nih.gov/pubmed/25201980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1409730111
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