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Aberrant calcium signaling by transglutaminase-mediated posttranslational modification of inositol 1,4,5-trisphosphate receptors
The inositol 1,4,5-trisphosphate receptor (IP(3)R) in the endoplasmic reticulum mediates calcium signaling that impinges on intracellular processes. IP(3)Rs are allosteric proteins comprising four subunits that form an ion channel activated by binding of IP(3) at a distance. Defective allostery in I...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
National Academy of Sciences
2014
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4183345/ https://ncbi.nlm.nih.gov/pubmed/25201980 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1409730111 |
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