Aberrant calcium signaling by transglutaminase-mediated posttranslational modification of inositol 1,4,5-trisphosphate receptors

The inositol 1,4,5-trisphosphate receptor (IP(3)R) in the endoplasmic reticulum mediates calcium signaling that impinges on intracellular processes. IP(3)Rs are allosteric proteins comprising four subunits that form an ion channel activated by binding of IP(3) at a distance. Defective allostery in I...

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Hlavní autoři: Hamada, Kozo, Terauchi, Akiko, Nakamura, Kyoko, Higo, Takayasu, Nukina, Nobuyuki, Matsumoto, Nagisa, Hisatsune, Chihiro, Nakamura, Takeshi, Mikoshiba, Katsuhiko
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2014
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PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183345/
https://ncbi.nlm.nih.gov/pubmed/25201980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1409730111
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