Oligomerization of KCC2 Correlates with Development of Inhibitory Neurotransmission

The neuron-specific K(+)–Cl(−) cotransporter KCC2 extrudes Cl(−) and renders GABA and glycine action hyperpolarizing. Thus, it plays a pivotal role in neuronal inhibition. Development-dependent KCC2 activation is regulated at the transcriptional level and by unknown posttranslational mechanisms. Her...

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Pubblicato in:J Neurosci
Autori principali: Blaesse, Peter, Guillemin, Isabelle, Schindler, Jens, Schweizer, Michaela, Delpire, Eric, Khiroug, Leonard, Friauf, Eckhard, Nothwang, Hans Gerd
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6674702/
https://ncbi.nlm.nih.gov/pubmed/17035525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3257-06.2006
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