Deletion of the GABA(A) Receptor α1 Subunit Increases Tonic GABA(A) Receptor Current: A Role for GABA Uptake Transporters

The loss of more than half the number of GABA(A) receptors yet lack of pronounced phenotype in mice lacking the gene for the GABA(A) α1 subunit is somewhat paradoxical. We explored the role of tonic GABA(A) receptor-mediated current as a target of compensatory regulation in the α1 knock-out (−/−) mi...

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Udgivet i:J Neurosci
Main Authors: Ortinski, Pavel I., Turner, Jill R., Barberis, Andrea, Motamedi, Gholam, Yasuda, Robert P., Wolfe, Barry B., Kellar, Kenneth J., Vicini, Stefano
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2006
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6674491/
https://ncbi.nlm.nih.gov/pubmed/16957088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2610-06.2006
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